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An Integrated Project financially supported by a grant from the European Commission (PL037712)

Workpackages

• Select model compounds for all in vitro systems.

• Various approaches will be compared to achieve the ultimate goal of developing an in vitro hepatic system showing the appropriate features of the organ in vivo.

• A number of robust, established renal cell culture model systems will be used to assess the effects of selected model carcinogens.

• This Workpackage will develop a detailed understanding of the pivotal role played by lung epithelial cells in the induction of lung carcinogenesis.

• All microarray data experiments for this project will be standardized using one platform, the Affymetrix GeneChip® platform.

• The central aim of this Workpackage will be to develop metabonomic assays for prediction of carcinogenicity in addition to providing supporting data for pathway analysis and model validation.

• This is an extensive Workpackage devoted to data storage, statistical data analysis and pathway analysis and in silico modelling.

• WP8 is expected to add high throughput features in order to facilitate the analysis of specific genomic responses to human carcinogens at high reliability and speed, and at low cost.

• ECVAM will take the lead to prevalidate the in vitro test methods according to ECVAM's internationally accepted criteria for prevalidation.

• Training and educational activities among carcinoGENOMICS researchers by a) transfer of knowledge and scientific skills; b) exchange of researchers between laboratories; c) networking of existing training and research; d) practical training on the best available technologies.

• Organization of the flow of scientific information within the carcinoGENOMICS network and dissemination of information regarding the results of the research performed in the Project WPs, as well as relevant scientific findings from the wider scientific community.

• Management of the whole carcinoGENOMICS Project.